羧甲基纤维素钠修饰对高离子强度下脂质体稳定性的影响

Liposomes have obvious advantages as carriers of hydrophobic substances such as plant essential oils. However, the electrostatic shielding effect at high ionic strength can lead to poor colloidal stability of liposome and limit its application. Sodium carboxymethyl cellulose (CMCNa) has salt tolerance, so in this paper, CMCNa was used to modify cinnamaldehyde liposome in order to improve its stability under high ionic strength. Based on the analysis of liposome appearance, particle size, encapsulation efficiency, retention rate and rheological properties, it was investigated that the effects of the molecular structure and concentration of CMCNa on liposome physical stability. The results showed that the viscoelasticity of liposomes was improved by the addition of CMCNa, and the relative molecular weight and concentration of CMCNa were positively relative to the improvement of the aggregation of liposome particles. The effect of CMCNa on the colloidal stability of liposomes was the most obvious when the degree of substitution of CMCNa was 0.90 and the concentration was 0.8% (w/v). Under the condition, the retention rate of cinnamaldehyde in liposomes was about 80% after incubating for 6 h at 45 ℃.