Leveraging serology testing to identify children at risk for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the RECOVER program
Leveraging serology testing to identify children at risk for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the RECOVER program
ABSTRACT The impact of post-acute sequelae of SARS-CoV-2 infection (PASC) in children is underrecognized. We developed an EHR-based algorithm across eight pediatric institutions to identify children with COVID-19 based on serology testing from 3/2020 through 4/2022 who had not been identified by PCR. Overall, serology tests were used 100-fold less than PCR. Seroprevalence of IgG anti-nucleocapsid antibodies remained stable, while rates of positive IgG anti-spike antibodies increased in teenagers after COVID-19 vaccine approval. Through data harmonization and after excluding 1,410 serology test results that may have been influenced by vaccines, we identified 2,714 children that were COVID-19 positive exclusively by serology. These patients were frequently tested as inpatients (24% vs. 2%), had chronic conditions more frequently (37% vs 24%), and a MIS-C diagnosis (23% vs. <1%) compared with PCR-positive children. Identification of children that could have been paucisymptomatic, not tested, or missed is critical to define the burden of PASC in children.
Pajor Nathan M.、Jhaveri Ravi、Bennett Tellen D.、Thacker Deepika、Razzaghi Hanieh、Schuchard Julia、Bailey L. Charles、Mejias Asuncion、Rao Suchitra、Lee Grace M.、Christakis Dimitri A.、Forrest Christopher B.
Division of Pulmonary Medicine, Cincinnati Children?ˉs Hospital Medical Center and University of Cincinnati College of MedicineDivision of Infectious Diseases, Ann & Robert H. Lurie Children?ˉs Hospital of ChicagoDepartment of Pediatrics, University of Colorado School of Medicine and Children?ˉs Hospital ColoradoDivision of Cardiology, Nemours Children?ˉs HealthApplied Clinical Research Center, Children?ˉs Hospital of PhiladelphiaApplied Clinical Research Center, Children?ˉs Hospital of PhiladelphiaApplied Clinical Research Center, Children?ˉs Hospital of PhiladelphiaDivision of Infectious Diseases, Department of Pediatrics, Nationwide Children?ˉs Hospital and The Ohio State UniversityDepartment of Pediatrics, University of Colorado School of Medicine and Children?ˉs Hospital ColoradoDepartment of Pediatrics (Infectious Diseases), Stanford University School of MedicineCenter for Child Health, Behavior and Development, Seattle Children?ˉs HospitalApplied Clinical Research Center, Children?ˉs Hospital of Philadelphia
医学研究方法儿科学医药卫生理论
PEDSnetCOVID-19 serologyanti-N antibodiesanti-S antibodiespost-acute sequelae COVID-19long COVIDChronic COVID-19 SyndromeLate sequelae of COVID-19Long haul COVID-19Long-term COVID-19Post COVID-19 syndromePost-acute COVID-19Post-acute sequelae of SARS-CoV-2 infection
Pajor Nathan M.,Jhaveri Ravi,Bennett Tellen D.,Thacker Deepika,Razzaghi Hanieh,Schuchard Julia,Bailey L. Charles,Mejias Asuncion,Rao Suchitra,Lee Grace M.,Christakis Dimitri A.,Forrest Christopher B..Leveraging serology testing to identify children at risk for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the RECOVER program[EB/OL].(2025-03-28)[2025-08-06].https://www.medrxiv.org/content/10.1101/2022.06.20.22276645.点此复制
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