ZNF268在卵巢癌细胞中的异常表达可导致细胞生长和迁移行为发生改变
berrant Expression of ZNF268 Alters the Growth and Migration of Ovarian Cancer Cells
卵巢癌是全球范围内最致命的妇科肿瘤之一，然而其肿瘤发生的分子机理还并不十分清楚。本文研究结果表明：ZNF268基因异常高表达于人类卵巢癌组织中。在SKOV-3卵巢癌细胞中，下调ZNF268基因的表达，可以促进细胞活性，增强其克隆形成能力，促进裸鼠肿瘤移植物的生长；而SKOV-3癌细胞的迁移则受到ZNF268基因下调的抑制。此外，结果还表明，ZNF268的表达下调是通过促进细胞周期的进程而增强细胞的生长能力的。因此，本文研究结果显示，ZNF268是一种新的与卵巢癌发生发展过程相关的蛋白，这些研究结果可以更好地帮助我们理解卵巢癌的发生发展过程的分子机制。
Ovarian cancer is one of the most lethal gynaecologic cancers worldwide. However, the mechanism underlying ovarian carcinogenesis is not well understood. Here, we show that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268 knockdown increased the viability, colony formation, and the growth of in vivo xenografts of ovarian carcinoma SKOV-3 cells, whereas SKOV-3 cell migration was inhibited by ZNF268 knockdown. Furthermore, we demonstrated that ZNF268 knockdown may increase SKOV-3 cell growth by promoting cell cycle progression. Our findings suggest that ZNF268 is a novel protein involved in ovarian carcinogenesis and may help us better understand the mechanism of ovarian carcinogenesis.
胡丽、郭明雄、汪维、蔡锦阳、熊世禄、罗峻、黄奕、李文鑫
肿瘤学妇产科学基础医学
ZNF268卵巢癌SKOV-3细胞
ZNF268Ovarian cancerSKOV-3 cells
胡丽,郭明雄,汪维,蔡锦阳,熊世禄,罗峻,黄奕,李文鑫.ZNF268在卵巢癌细胞中的异常表达可导致细胞生长和迁移行为发生改变[EB/OL].(2013-01-07)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/201301-297.点此复制
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