IFB反应合成2,3-二氢呋喃类衍生物

ihydrofurans are an important class of heterocyclic compounds. For their special chemical properties, they have found wide applications in the synthesis of pharmaceuticals and chemical intermediates etc. Chiral 2,3-dihydrofurans are highly important building blocks for the synthesis of numerous natural products (e.g. polyether antibiotics, lignans, nucleoside) and some chiral pharmaceuticals.This work, synthesis of β-carbonyl nitriles benzoylacetonitrile and adamantane formyl acetonitrile was prepared with adamantane formic acid and ethyl ester, which was carried out with ethyl bromopyruvate to give 4-cyano furan-2,3-dihydro derivatives.