胰腺神经内分泌肿瘤
pancreatic neuroendocrine tumors
胰腺神经内分泌肿瘤(pancreatic neuroendocrine tumors, PNETs)是一类源于胰腺多能神经内分泌干细胞的肿瘤,近年来,有资料显示其发病率呈现出一个逐年增加的趋势,但从总体上看,其发病率低,肿瘤通常较小(<1cm),生长速度较慢(数月或数年),症状既可呈阶段性表达亦可数年无症状。而且,在出现症状前多有肝脏和骨骼等部位的转移,此时,肿瘤的体积通常>2cm,易与内分泌原发疾病相混淆,误诊、漏诊现象常见。然而,部分胰腺神经内分泌肿瘤恶性程度较低,临床上如能及早诊断、及时治疗,则常能收到一个较好的预后效果。而且近年来,学术界对胰腺神经内分泌肿瘤的认识也发生了很大的改变,其诊断和治疗模式亦相应变迁,已成为研究的热点。鉴于此种情况,本文着重从诊断、治疗和预后入手,对其作一综述。
Pancreatic neuroendocrine tumors ( PNETs) are a class of tumors that derived from the pluripotent neural stem cells of pancreas.In recent years, some data shows a yearly increasing trend of the incidence of PNET. However, the overall incidence of PNETs is low.Generally, the tumor volume is small(<1cm)and the growth rate is slow (several months or several years).But,its symptoms can be periodical expression or no symptoms for years.Furthermore,before the onset of symptoms,the tumors have transfered to liver and bones and other parts of the body.At this point, the tumor volume usually exceeds 2cm, which is easily confused with endocrine primary disease, resulting in misdiagnosis and missed diagnosis. However, some pancreatic neuroendocrine tumors, malignant level is lower.If it can get a early diagnosis and timely treatment in the clinical,it will get a better prognosis. And in recent years, with the change of the academic understanding of pancreatic neuroendocrine tumors,its diagnosis and treatment patterns also change accordingly,it has become a research hot spot. In view of the situation,in this article ,we will write a review of PNETs mainly from its diagnosis,treatment and prognosis.
姜脉涛、白雪巍、邵光东
肿瘤学临床医学内科学
胰腺神经内分泌肿瘤诊断治疗预后
Pancreatic neuroendocrine tumorsdiagnosistreatmentprognosis
姜脉涛,白雪巍,邵光东.胰腺神经内分泌肿瘤[EB/OL].(2014-01-10)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201401-505.点此复制
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