二甲双胍减轻体重的分子的机制

In this paper, we investigated the molecular mechanism of metformin on weight loss in mice.Mice were randomly divided into CON group (standard diet), HFD group (high-fat diet), and HFD+MET (metformin) group. Mice in HFD+MET group showed lower body weight and white adipose tissue (WAT) mass in comparison to those in HFD group.Adipogenic genes were down-regulated after metformin treatment. Interestingly, metformin treatment down-regulated the protein level of insulin receptor (IR) whereas, up-regulated the protein level of IR in skeletal muscle.Our results indicated that metformin prevented weight gain through the specific down-regulation of insulin signaling pathway in WAT.