甲氨蝶呤致胃肠功能障碍研究进展

Methotrexate is one of the mainly chemotherapy drugs in cancer therapy,as a cell cycle-specific drugs,mucositis is a common side effect, but also a major cause of morbidity and occasional mortality during cancer treatments. It can compromise quality of life and often limits the dose, duration and thus treatment effectiveness of chemotherapy in susceptible patients.It has become a gradually increasing problem in the chemotherapy regimens. Now there are many studies on pathophysiological mechanisms of intestinal mucosal damage and repair and developing potential interventions to prevent or to treat this side effect of cancer therapy. This article is to explore its mechanism and mucosal repair-related cytokines and drugs.