Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies
Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies
Abstract Pathophysiological models are urgently needed for personalized treatments of mental disorders. However, most potential neural markers for psychopathology are limited by low interpretability, prohibiting reverse inference from brain measures to clinical symptoms and traits. Neural signatures—i.e. multivariate brain-patterns trained to be both sensitive and specific to a construct of interest—might alleviate this problem, but are rarely applied to mental disorders. We tested whether previously developed neural signatures for negative affect and discrete emotions distinguish between healthy individuals and those with mental disorders characterized by emotion dysregulation, i.e. Borderline Personality Disorder (BPD) and complex Post-traumatic Stress Disorder (cPTSD). In three different fMRI studies, a total sample of 192 women (49 BPD, 62 cPTSD, 81 healthy controls) were shown pictures of scenes with negative or neutral content. Based on pathophysiological models, we hypothesized higher negative and lower positive reactivity of neural emotion signatures in participants with emotion dysregulation. The expression of neural signatures differed strongly between neutral and negative pictures (average Cohen’s d = 1.17). Nevertheless, a mega-analysis on individual participant data showed no differences in the reactivity of neural signatures between participants with and without emotion dysregulation. Confidence intervals ruled out even small effect sizes in the hypothesized direction and were further supported by Bayes factors. Overall, these results support the validity of neural signatures for emotional states during fMRI tasks, but raise important questions concerning their link to individual differences in emotion dysregulation.
Schmahl C.、Niedtfeld I.、M¨1ller-Engelmann M.、Sicorello M.、Herzog J.、Ende G.、Herpertz S.C.、Wager T.D.、Bohus M.、Paret C.
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg UniversityDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg UniversityDepartment of Clinical Psychology and Intervention, Institute of Psychology, Goethe-University FrankfurtDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg UniversityDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg UniversityDepartment Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of General Psychiatry, Center for Psychosocial Medicine, Heidelberg UniversityDepartment of Psychological and Brain Sciences, Dartmouth CollegeInstitute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim, Heidelberg UniversityDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University||Sagol Center for Brain Function, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center and Sagol School of Neuroscience, School of Psychological Sciences and Faculty of Medicine, Tel-Aviv University
神经病学、精神病学医学研究方法基础医学
neuroimagingemotion regulationborderline personality disorderpost-traumatic stress disorderneural signaturemeta-analysis
Schmahl C.,Niedtfeld I.,M¨1ller-Engelmann M.,Sicorello M.,Herzog J.,Ende G.,Herpertz S.C.,Wager T.D.,Bohus M.,Paret C..Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies[EB/OL].(2025-03-28)[2025-05-06].https://www.medrxiv.org/content/10.1101/2021.02.03.21251077.点此复制
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