Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance
Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance
Abstract B cell fate decisions within a germinal center (GC) are critical to determining the outcome of the immune response to a given antigen. Here, we characterize GC kinetics and B cell fate choices in a response to the autoantigen myelin oligodendrocyte glycoprotein (MOG), and compare them the response to a standard model foreign antigen (NP-haptenated ovalbumin, NPOVA). Both antigens generated productive primary responses, as evidenced by GC development, circulating antigen-specific antibodies, and differentiation of memory B cells. However, in the MOG response the status of the cognate T cell partner drove preferential B cell differentiation to a memory phenotype at the expense of GC maintenance, resulting in a truncated GC. Reduced plasma cell differentiation was largely independent of T cell influence. Interestingly, memory B cells formed in the MOG GC were unresponsive to secondary challenge and this could not be overcome with T cell help.
Parham Kate A、Kerfoot Steven M、Tesfagiorgis Yodit、Craig Heather C、Jain Rajiv W、Romanchik Emiliano
Department of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western OntarioDepartment of Microbiology and Immunology, University of Western Ontario
基础医学
B cellT follicular helper cellautoimmunitygerminal centerMOGmemory B cellplasma cellMultiple Sclerosis
Parham Kate A,Kerfoot Steven M,Tesfagiorgis Yodit,Craig Heather C,Jain Rajiv W,Romanchik Emiliano.Autoreactive T cells preferentially drive differentiation of non-responsive memory B cells at the expense of germinal center maintenance[EB/OL].(2025-03-28)[2025-05-08].https://www.biorxiv.org/content/10.1101/287789.点此复制
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