四硫酸软骨素抑制草酸钙结晶的动力学研究

he effect of Ch4S on the growth rate and morphology of spiral steps on COM (-101) face and (010) face was observed by means of in situ AFM under the different supersaturated solution. The results showed that the velocity along [100] and [0-2-1] directions have slowed down, and the spiral speed of spiral steps along [100] direction was significantly slower than that of [0-2-1] direction with the increasing of the concentration of Ch4S on (010) face of calcium oxalate crystal.Which makes the morphology of hillocks consisiting of [100] direction for the short side and [0-2-1] direction for the long side of the Inhibition Mechanisms of Crystallization Kinetics of Calcium Oxalates by Chondroitin 4?Sulfateparallelogram, gradually into the direction of the two directions equal to the square,then become parallelogram again which developed into [0-2-1] direction for the short side and [100] direction for the long side.Following the spiral steps become disturbed and rough,and the speed of spiral steps approach to zero at the top concentration of Ch4S on (010) face of calcium oxalate crystal.This indicates that the edge of steps along [100] direction has a rich in calcium site was exposure,which makes Ch4S easier to be absorbed,with the significantly inhibiting the growth of the step in this direction.Comparing the velocitiy of steps on (-101) face with that on (010) face,the relative velocitiy of steps along [101] direction on (-101) is three times as quick as that of [100] direction and [0-2-1] direction on (010) face. It shows that the function group of Ch4S (such as Sulfuric acid group, carboxyl group) and the surface of calcium oxalate crystal under the combined action of adsorption and hydration have different ability to compete for binding sites,finally the inhibitory effect on (010) plane more significantly than that of the (-101) surface.