女性高危型人乳头瘤病毒感染2501例调查
目的 了解广州地区2013年和2014年女性高危型HPV感染情况，对该地区宫颈癌的预防和疫苗的开发提供指导。方法采用荧光PCR分型定性检测方法，对2501例来院就诊的女性患者或体检者宫颈分泌物中的13种高危型HPV特异性DNA核酸片段进行检测。结果 2013年和2014年高危型HPV总感染率分别为14.85%（146/983）、14.56%（221/1518），差异无统计学意义（χ2=0.041，P=0.839）。各年内各年龄段感染率差异亦无统计学意义（χ2=2.916，P=0.572；χ2=6.494，P=0.165）。2013年和2014年HPV亚型的总体构成比差异无统计学意义（χ2=11.872，P=0.452），2013年各亚型感染频次构成比从高到低依次为HPV52、16、58、56、39、51、68、59、31、35、18、33、45型，而2014年为HPV52、16、58、68、18、51、56、39、31、33、59、35、45型。结论 广州地区女性高危型HPV感染率较高，各年龄段女性均应定期进行高危型HPV筛查，以预防和早期发现宫颈癌。开发新的多价疫苗或通用疫苗预防HPV感染，从而降低宫颈癌的发病率。
Objective To survey the prevalence of high-risk human papillomavirus (HPV) in woman in Guangzhou during the period from 2013 to 2014. Methods A total of 2501 women in Guangzhou seeking medical attention in our hospital underwent high-risk HPV genotype screening of cervical specimens using real-time PCR. Results The prevalence of high-risk HPV infection among the women was 14.85% (146/983) in the year 2013, similar to the rate of 14.56% (221/1518) in 2014 (2=0.041, P= 0.839); no significant differences were found in the high-risk HPV infection rates between different age groups in either 2013 (2=2.916, P=0.572) or 2014 (2=6.494, P=0.165). The constituent ratio of the 13 types of high-risk HPV showed no significant difference between 2013 and 2014 (2=11.872, P=0.452). The 13 HPV genotypes detected, listed in a descending order of the constituent ratios, included HPV-52, -16, -58, -56, -39, -51, -68, -59, -31, -35, -18, -33 and -45 in 2013, and were HPV-52, -16, -58, -68, -18, -51, -56, -39, -31, -33, -59, -35 and-45 in 2014. Conclusion We report a high prevalence of high-risk HPV among women in Guangzhou, which suggests the necessity of screening for high-risk HPV-DNA among women at all ages for prevention and early detection of cervical cancer.
杨永泉、李林海、张卫云、唐荣芝、孙朝晖、陈丽丹、陈静娜
预防医学妇产科学肿瘤学
高危型HPV广州地区流行病学
杨永泉,李林海,张卫云,唐荣芝,孙朝晖,陈丽丹,陈静娜.女性高危型人乳头瘤病毒感染2501例调查[EB/OL].(2017-12-07)[2025-08-16].https://chinaxiv.org/abs/201712.00751.点此复制
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