针刺调节抵抗素抑制肥胖患者脂毒性作用的临床观察
he clinical study of connection serum resistin with acupuncture represses lipotoxicity in the patients with simply obesity
背景：血浆游离脂肪酸的升高导致机体的脂毒性，脂毒性是肥胖并发糖尿病的核心环节，针刺可以减肥，是否也具有抑制脂毒性的作用、其可能机制是什么？方法：临床针刺治疗34例单纯性肥胖病患者3个疗程，治疗前后测量体重指数(BMI)、脂肪百分率(F%)，酶联免疫法测定血清胰岛素、抵抗素，生化比色法测定血脂、血糖，高效液相色谱法测定主要的八种游离脂肪酸，并与20例正常人对照。结果：①临床总有效率88.23%，针刺可提高患者降低的胰岛素敏感指数（IAI，t =-5.103， p =0.000）。②针刺后F%的降低与不饱和脂肪酸的升高的相关具有显著性意义（r=0.402，p=0.019），与不饱和脂肪酸与饱和脂肪酸的比值的升高的相关性亦具有显著性意义（r=0.348，p=0.044）。高密度脂蛋白升高与二十碳五烯酸的升高的相关性具有显著性意义（r=0.352，p=0.041），BMI的降低与高密度脂蛋白的升高的相关具有显著性意义（r=0.357，p=0.038）。③治疗后抵抗素水平较治疗前的差异(降低)有显著意义（p=0.028），与正常人较接近（p=0.110），F%降低与抵抗素降低的相关性具有显著性意义（r=0.380，p=0.027）。结论：针刺可以降低患者的游离脂肪酸水平、提高其胰岛素敏感性，从而表现出抑制脂毒性的效应。针刺减少体脂抑制脂毒性的作用与降低抵抗素水平有一定的关系。
bstract] Objective: To observe curative effect of acupuncture at the patients with. Simply obesity. To investigates the mechanism of repress lipotoxicity. Methods: To investigate curative effect of acupuncture at the patients with simply obesity with scores of BMI and F%. The levels serum resistin measured with ELISA .The levels free fat acids in plasm a were assayed HPLC. Results: The overall response rate of acupuncture in the patients with simply obesity was 88.23%. The analysis show the change of between scores of F% with the patient and change of levels in the plasma Unsaturated fatty acid（r=0.402，p=0.019）have remarkable correlation . The analysis show the change of between scores of resistin and free fat acids（r=-0.349，p=0.043）have remarkable correlation Conclusion: The acupuncture may repress lipotoxicity. The acupuncture accommodated resistin is one may approach contributory to repress lipotoxicity.
吕雅妮、陈梅、王欣君、刘志诚、徐斌、姜军作、袁锦虹
中医学临床医学基础医学
针刺，单纯性肥胖病，脂毒性，抵抗素
cupuncturesimply obesitylipotoxicityresistin
吕雅妮,陈梅,王欣君,刘志诚,徐斌,姜军作,袁锦虹.针刺调节抵抗素抑制肥胖患者脂毒性作用的临床观察[EB/OL].(2007-11-08)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/200711-171.点此复制
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