血尿酸水平与2型糖尿病发病风险关联研究
Association between serum uric acid and the risk of type 2 diabetes mellitus: a population-based cohort study
背景 血尿酸（SUA）升高导致的高尿酸血症（HUA）高发，已成为我国继高血糖、高血脂、高血压的第四高疾病，继糖尿病之后的第二大代谢性疾病。已有证明表明，SUA水平升高与2型糖尿病（T2MD）发病风险有显著关联。目的 探讨健康体检人群基线SUA水平与T2DM发病风险的关联。方法 选取从2017年1月至2020年12月至少有2次健康体检的17626名基线无糖尿病病史的体检人群，收集其人口学信息、生活方式信息、体格检查信息及实验室指标信息，采用Cox比例风险回归模型分析基线不同SUA水平与T2DM发病风险关联。结果 研究对象中位年龄38.15（31.89，49.59）岁，基线中位SUA水平304.50（248.00，374.00）umol/L，HUA总患病率为13.12%。累积随访54634人年，中位随访3.10年，T2DM新发479例，发病密度为8.76/1000人年（95%CI：8.00/1000-9.59/1000人年），累积发病率为2.72%（95%CI：2.48-2.97%）。高年龄组（≥ 60岁）、女性、目前吸烟、目前饮酒、BMI ≥ 28.0 Kg/m2、患高血压及血脂异常亚组人群中T2MD累积发病率更高，且伴随HUA时T2DM的发病风险也更高。多因素调整后Cox比例风险回归模型分析结果显示，HUA患者中T2DM发病风险增加，HR值为1.32（95%CI：1.04，1.67；P=0.023）；且随SUA水平升高，SUA高值组T2DM的发病风险更高（P趋势性<0.001）。基线SUA水平每升高10 umol/L，T2DM的发病风险增加3%（95%CI：1%-4%，P<0.001）。结论 健康体检人群基线SUA水平升高与T2DM的高发病风险相关。
医药卫生理论医学研究方法内科学
2型糖尿病血尿酸高尿酸血症发病风险队列研究
高鹰,宋华隆.血尿酸水平与2型糖尿病发病风险关联研究[EB/OL].(2022-11-16)[2025-11-07].https://chinaxiv.org/abs/202211.00233.点此复制
Background Hyperuricemia (HUA) caused by elevated serum uric acid (SUA) has become the fourth most common disease after hyperglycemia, hyperlipidemia, and hypertension, and the second most common metabolic disease after diabetes. It has been shown that elevated SUA levels were significantly associated with the risk of type 2 diabetes mellitus (T2DM). Objective To investigate the association between baseline SUA levels and the risk of T2DM in health examination population. Methods A total of 17626 subjects without diabetes history at baseline who had underwent at least two physical examination from January 2017 to December 2020 were selected to collect demographic information, lifestyle information, physical examination information, and laboratory indicators. Cox proportional risk model was used to analyze the association between baseline SUA levels and the risk of T2DM. Results The median age of subjects were 38.15 (31.89, 49.59) years. The median SUA levels at baseline were 304.50 (248.00, 374.00) umol/L and the prevalence of HUA was 13.12%. The cumulative follow-up was 54634 person-years, with a median follow-up of 3.10 years. There were 479 new cases of T2DM. The incidence density was 8.76/1000 person-years (95%CI: 8.00/1000 - 9.59/1000 person-years) and the cumulative incidence rate was 2.72% (95%CI: 2.48 - 2.97%). There were high cumulative incidence rate of T2DM in high age group (≥ 60 years old), female, current smoking, current alcohol consumption, BMI ≥ 28.0 Kg/m2, hypertension, and dyslipidemia subgroups, and higher risk of T2DM when those subgroup population accompany with HUA. The result of multivariate adjusted Cox proportional risk regression model showed that HUA patients had an increased risk of T2DM, with an HR of 1.32 (95%CI1.04, 1.67; P=0.001). The risk of T2DM was higher in high SUA groups with the increase of SUA level (Ptrend <0.001). For every 10 umol/L increase in baseline SUA level, the risk of T2DM increased by 3% (95%CI1%-4%, P<0.001). Conclusion Elevated baseline SUA levels in health examination population are associated with a higher risk of T2DM.
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