短期化疗对乳腺癌组织UCH-L1表达的影响

Objective　 To observe the effects of MDR drugs on the expression of UCH-L1, EGFR and P-gp in the breast carcinoma before and after short-term chemotherapy. Methods The expression of UCH-L1, EGFR and P-gp were assessed by immunohistochemistry (EnVision method) in 40 cases breast carcinoma before and after treatment by MDR drugs (paclitaxel and epirubicin). Results The expression of EGFR was decreased after chemotherapy with MDR drugs(P<0.05). Same as increased EGFR(P<0.01), the expression of P-gp was also increased after chemotherapy, while the changes showed no statistical significance. Negative associations were revealed between UCH-L1, EGFR, and P-gp expression and volume reduce of tumor and LN metastasis. Conclusions Short-term chemotherapy can kill tumor cells and influence the expression of UCH-L1, EGFR, and P-gp. While the involved mechanisms may be the selectivity damage of the MDR drugs on the tumor cells. And also, they are not lead to the expression of CD147 and other downstream factors that enough to cause the invasion of tumor cells.