Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19
Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19
Abstract Plasma SARS-CoV-2 viral RNA (vRNA) levels are predictive of COVID-19 outcomes in hospitalized patients, but whether plasma vRNA reflects lower respiratory tract (LRT) vRNA levels is unclear. We compared plasma and LRT vRNA levels in simultaneously collected longitudinal samples from mechanically-ventilated patients with COVID-19. LRT and plasma vRNA levels were strongly correlated at first sampling (r=0.83, p<10?8) and then declined in parallel except in non-survivors who exhibited delayed vRNA clearance in LRT samples. Plasma vRNA measurement may offer a practical surrogate of LRT vRNA burden in critically ill patients, especially early in severe disease.
Bain William、Naqvi Asma、Boltz Valerie F.、McVerry Bryan J.、Ray Prabir、Schaefer Caitlin、Meth¨| Barbara、Lee Janet、Morris Alison、Mellors John W.、Kitsios Georgios D.、Kearney Mary F.、Shah Faraaz A.、Fitzpatrick Meghan、Jacobs Jana L.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh||Veteran?ˉs Affairs Pittsburgh Healthcare SystemUniversity of Pittsburgh School of Medicine, Department of Medicine, Division of Infectious DiseasesHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer InstituteDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh||Center for Medicine and the Microbiome, Department of Medicine, University of PittsburghDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of MedicineDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Acute Lung Injury Center of Excellence, Department of Medicine, University of PittsburghDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Center for Medicine and the Microbiome, Department of Medicine, University of PittsburghDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Acute Lung Injury Center of Excellence, Department of Medicine, University of PittsburghDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Center for Medicine and the Microbiome, Department of Medicine, University of PittsburghUniversity of Pittsburgh School of Medicine, Department of Medicine, Division of Infectious DiseasesDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh||Center for Medicine and the Microbiome, Department of Medicine, University of PittsburghHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer InstituteDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine||Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh||Veteran?ˉs Affairs Pittsburgh Healthcare SystemDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of MedicineUniversity of Pittsburgh School of Medicine, Department of Medicine, Division of Infectious Diseases
医学研究方法基础医学临床医学
COVID-19SARS-CoV-2viremiaRNAemia
Bain William,Naqvi Asma,Boltz Valerie F.,McVerry Bryan J.,Ray Prabir,Schaefer Caitlin,Meth¨| Barbara,Lee Janet,Morris Alison,Mellors John W.,Kitsios Georgios D.,Kearney Mary F.,Shah Faraaz A.,Fitzpatrick Meghan,Jacobs Jana L..Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2022.01.10.22269018.点此复制
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