解脂耶氏酵母发酵产α-酮戊二酸研究进展
Review of α-Ketoglutaric acid production by Yarrowia Lipolytica
本文综述了国内外解脂耶氏酵母（Yarrowia Lipolytica）发酵生产α-酮戊二酸的相关研究进展。对发酵法生产α-酮戊二酸的研究历程，解脂耶氏酵母生物合成α-酮戊二酸的代谢途径，以及影响α-酮戊二酸过量积累的主要因素进行了介绍。本文分析了发酵产α-酮戊二酸存在的困难，并提出了高产α-酮戊二酸菌株的构建思路，以期有助于该领域的研究工作。
his review presents a summary of recent research results in biotechnological production of α-ketoglutaric acid (KGA) by yeast Yarrowia lipolytica. The research progress of KGA biosynthesis, the related metabolic pathways of KGA in Yarrowia lipolytica, as well as the factors which influence KGA overproduction were introduced. Based on evaluation of the difficulties existent in KGA biosynthesis, strategy of constructing high-yield KGA producing strain was proposed.
巩健、宋健
生物工程学生物化学微生物学
α-酮戊二酸解脂耶氏酵母生物合成
α-ketoglutaric acidYarrowia lipolyticabiosynthesis
巩健,宋健.解脂耶氏酵母发酵产α-酮戊二酸研究进展[EB/OL].(2013-06-08)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/201306-121.点此复制
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