乳腺癌组织中MT1-MMP、VEGF的表达及其相关性
he Expression of MT1-MMP and VEGF in breast cancer tissue and their correlation
目的： 探讨MT1-MMP和VEGF在乳腺癌组织中的表达及其与乳腺癌临床病理特征间的关系。方法： 采用免疫组织化学方法检测67例乳腺癌组织和癌旁正常组织中MT1-MMP和VEGF的表达情况，并与临床病理特征进行相关性分析。 结果：MT1-MMP和VEGF在乳腺癌组织中的表达水平显著高于在癌旁正常组织中的表达水平( P＜0.05) 。VEGF 和MT1-MMP在乳腺癌组织中的表达呈正相关( P=0.005)。VEGF表达与乳腺癌的TNM分期和淋巴结转移相关( P < 0.05) ； MT1-MMP表达与乳腺癌的TNM分期和腋窝淋巴结转移相关( P< 0. 05) 。结论：MT1-MMP和VEGF的过表达与乳腺癌的浸润转移有关，二者的联合检测对判断乳腺癌的恶性程度和预后具有重要价值。
Objective To explore the expression of MT1-MMP and VEGF in breast cancer tissue and their association with the clinicopathological features of breast cancer. Methods The immunohistochemical staining method was used to evaluate the expression of MT1-MMP and VEGF in 67 specimens of breast cancer and adjacent normal tissues, and its correlations to clinicopathological features were analyzed. Results The expression level of the MT1-MMP and VEGF in breast cancer tissues was markedly higher than that in the paraneoplastic breast tissue (P<0.05)。The expression of MT1-MMP was positively correlated with the expression of VEGF in breast cancer tissues ( P=0.005).The expressions of MT1-MMP and VEGF were positively correlated to TNM stage and axillary lymph node metastasis( P < 0.05)。Conclusions The increasing expressions of MT1-MMP and VEGF were correlated with invasion and metastasis of breast carcinoma, combined examine of VEGF and MT1-MMP can be of value in assessment of the malignancy and in prognostic evaluation of breast cancer.
庞达、王劲松、陈艳波、张国强
肿瘤学基础医学临床医学
乳腺癌MT1-MMPVEGF免疫组织化学
breast cancermembrane type-1 matrix metalloproteinase (MT1-MMP)vascular endothelial growth factor (VEGF)immunohistochemistry
庞达,王劲松,陈艳波,张国强.乳腺癌组织中MT1-MMP、VEGF的表达及其相关性[EB/OL].(2008-12-30)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/200812-990.点此复制
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