Resolvin D3 controls mouse and human nociceptive functions and preclinical progression of psoriasis
Resolvin D3 controls mouse and human nociceptive functions and preclinical progression of psoriasis
Summary Psoriasis is a chronic inflammatory skin disease caused by a complex interplay between the immune and nervous systems. Here, we found that resolvin D3 (RvD3) significantly prevented both skin inflammation and itch in a preclinical animal model of psoriasis induced by repeated applications of imiquimod. We also found that RvD3 anti-psoriatic effects resulted from the inhibition of nociceptive functions, which inhibition was replicated in human nociceptive neurons. We conclude that RvD3 and targeting nociceptive functions are promising strategies to treat psoriasis.
Berta Temugin、Lee Sang Hoon、Tonello Raquel、Im Sang-Taek、Jeon Hawon、Kim Yong Ho、Park Jeongsu、Davidson Steve、Park Chul-Kyu、Ford Zachary
Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical CenterPain Research Center, Department of Anesthesiology, University of Cincinnati Medical CenterPain Research Center, Department of Anesthesiology, University of Cincinnati Medical CenterGachon Pain Center and Department of Physiology, College of Medicine, Gachon UniversityDepartment of Health Sciences and Technology, GAIHST, Gachon UniversityGachon Pain Center and Department of Physiology, College of Medicine, Gachon University||Department of Health Sciences and Technology, GAIHST, Gachon UniversityDepartment of Health Sciences and Technology, GAIHST, Gachon UniversityPain Research Center, Department of Anesthesiology, University of Cincinnati Medical CenterGachon Pain Center and Department of Physiology, College of Medicine, Gachon University||Department of Health Sciences and Technology, GAIHST, Gachon UniversityPain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center
皮肤病学、性病学基础医学药学
PsoriasisSkin InflammationPruritusResolvin D3TRPV1CGRP
Berta Temugin,Lee Sang Hoon,Tonello Raquel,Im Sang-Taek,Jeon Hawon,Kim Yong Ho,Park Jeongsu,Davidson Steve,Park Chul-Kyu,Ford Zachary.Resolvin D3 controls mouse and human nociceptive functions and preclinical progression of psoriasis[EB/OL].(2025-03-28)[2025-05-02].https://www.biorxiv.org/content/10.1101/715169.点此复制
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