川芎化学成分的研究
hemical constituents of Ligusticum chuanxiong Hort.
目的：对川芎根茎(Ligusticum chuanxiong Hort.)的化学成分进行研究。方法：采用硅胶柱色谱、凝胶柱色谱、中压制备液相、高压制备液相等方法进行分离纯化，通过核磁共振、质谱等波谱手段对化合物进行结构鉴定。结果：从川芎根茎石油醚部位中分离了19个化合物，分别为3a-羟基-6-羰基-新蛇床酞内酯(1)、洋川芎内酯A(2)、藁本内酯(3)、Z-丁烯基苯酞(4)、丁苯酞(5)、洋川芎内酯 I(6)、洋川芎内酯 H(7)、洋川芎内酯 J(8)、洋川芎内酯 N(9)、3', 6', 8', 3a-diligustilide(10)、Chuanxiongnolide A(11)、Levistolide A(12)、Z-3',8',3'a-7'a-tetrahydro-6,3',7',7'a-diligustilide-8'-one(13)、Tokinolide B(14)、exo-Z,Z'-3a.7'a,7.3'a- diligustilide(15)、Z-6,8',7,3'-diligustilide(16)、5-羟甲基糠醛(17)、咖啡酸甲酯(18)、阿魏酸(19)。结论：19个化合物中包括9个苯酞类化合物(1~9)，其中(1)为新化合物，7个二聚苯酞类化合物(10~16)。?????
Objective：To isolate and identify the chemical constituents of Ligusticum chuanxiong Hort. Methods：Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, MPLC, and HPLC, and their structures were elucidated by the physicochemical properties and spectral analyses. Results：Nineteen chemical constituents were obtained and identified as 3a-hydroxy-6-carbonyl-neocnidilide (1), senkyunolide A (2), ligustilide (3), Z-butylidenephthalide (4), Butylphthalide (5), senkyunolide I (6), senkyunolide H (7), senkyunolide J (8), senkyunolide N (9), 3', 6', 8', 3a-diligustilide (10), Chuanxiongnolide A (11), Levistolide A (12), Z-3',8',3'a-7'a-tetrahydro-6,3',7',7'a-diligustilide-8'-one (13), Tokinolide B (14), exo-Z,Z'-3a.7'a,7.3'a- diligustilide (15), Z-6,8',7,3'-diligustilide (16), 5-(Hydroxymethyl)-2-furaldehyde (17), Methyl caffeate (18), Fumalic acid (19). Conclusion：Among the isolated 19 compounds, there are 9 phthalides (1~9), 7 dimerphthalides, and compound (1) is a new phthalide.
冯怡、梁爽、马强、房鑫
药学
中药化学川芎根茎化学成分苯酞类化合物二聚苯酞类化合物
chemistry of Chinese medicineLigusticum chuanxiong Hort.chemical constituentsphthalidedimerphthalide
冯怡,梁爽,马强,房鑫.川芎化学成分的研究[EB/OL].(2016-01-21)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201601-431.点此复制
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