胰岛素信号传导通路蛋白在子宫内膜癌中的表达及意义

Objective: To discuss the expression and significance of the key factors in insulin signaling pathway in endometrial carcinoma. Methods: The expressions of Grb-2、P-ERK protein in tissues from 51 cases of endometrial carcinoma, 10 cases of endometrial atypical hyperplasia, and 48 cases of normal endometrium were detected by using immunohistochemistry Elivison method and image analysis system. Results: The positive expression rate of Grb-2、P-ERK in normal endometrium, endometrial atypical hyperplasia and endometrial carcinoma had differences between them by statistic analysis (P<0.05). The positive expression rate of Grb-2 and P-ERK in endometrial carcinoma and the FIGO stage was of positive correlation (P<0.05). There were positive correlations among the expression rates of Grb-2--P-ERK in endometrial carcinoma; Conclusion: Insulin signaling pathway may play an important role in the incidence and development of endometrial carcinoma.