17β-雌二醇作用于超极化激活电流通道增强Ah型压力感受器神经元兴奋性
Modulation of 17β-estradiol on neuroexcitability by HCN channel in Ah-type baroreceptor neurons.
目的：研究17β-雌二醇 (17β-E2) 对雌鼠中兴奋阈值低、性别特异性分布的髓鞘化Ah型压力感受器神经元兴奋性的影响，并探讨其可能的作用机制。方法：迷走神经传入神经元的分离，主动脉减压神经标记，膜片钳电生理电生理技术，内脏感觉神经元的鉴别。结果：17β-E2潜在地激活了G蛋白偶联受体，可同步协同地调节HCN介导的AHPfast、ADPlate及RMP与阈电位。结论：17β-E2可经HCN增强Ah神经元的兴奋性。
Objective: To study the effects of 17β-estradiol on neuroexcitability in Ah-type baroreceptor neurons and to explore the involved mechanisms. Methods: Isolation of vagal afferent neurons, Aortic depressor nerve labeling, Electrophysiological techniques，Identification of neuronal cell types and data analysis. Results: Potentiated action of 17β-E2 on neuroexcitability is due to G-protein coupled receptor activation，HCN-mediated alternations in AHPfast, ADPlate, and RMP/threshold were synchronously and synergistically modulated by 17β-E2. Conclusion: The 17β-E2-mediated potentiation is confirmed in Ah-type baroreceptor neurons.
赵舒扬、陈佩、陈维然、李柏岩
基础医学生理学神经病学、精神病学
电生理学膜片钳技术性别差异压力感受器神经元超极化激活电流
kelectrophysiology patch clamp techniquegender difference baroreceptor neuron，hyperpolarization-activated current
赵舒扬,陈佩,陈维然,李柏岩.17β-雌二醇作用于超极化激活电流通道增强Ah型压力感受器神经元兴奋性[EB/OL].(2015-12-21)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201512-1047.点此复制
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