生物钟在免疫中的调控

he circadian clock is an intrinsic timekeeping mechanism enables organisms to adapt to day-night environmental changes. It regulates physiological and behavior activities in organisms in an approximate 24-hour cycle. The molecular mechanism of the circadian clock is composed of a transcriptional-translational feedback loop. Ample evidence reveals that the immune system, as an important defense mechanism of the body, is under circadian regulation. We summarize recent studies of the influence of the circadian clock on pathogen infection, the immune cells activities and immune disease. The complexs relationship between body clock, immune system, and other systems are also discussed. Finnally, we provide suggestions on the direction and importance of further research on the circadian clock and the immune system. (10 Points, Times New Roman)