Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19
Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19
STRUCTURED ABSTRACT BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the sole causative agent of coronavirus infectious disease-19 (COVID-19). MethodsWe performed a retrospective single-center study of consecutively admitted patients between March 1st and May 15th, 2020, with a definitive diagnosis of SARS-CoV-2 infection. The primary end-point was to evaluate the association of lipid markers with 30-days all-cause mortality in COVID-19. ResultsA total of 654 patients were enrolled, with an estimated 30-day mortality of 22.8% (149 patients). Non-survivors had lower total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) levels during the entire course of the disease with complete resolution among survivors. Both showed a significant inverse correlation with inflammatory markers and a positive correlation with lymphocyte count. In a multivariate analysis, LDL-c ≤ 69 mg/dl (hazard ratio [HR] 1.94; 95% confidence interval [CI] 1.14-3.31), C-reactive protein > 88 mg/dl (HR 2.44; 95% CI, 1.41-4.23) and lymphopenia < 1,000 (HR 2.68; 95% CI, 1.91-3.78) at admission were independently associated with 30-day mortality. This association was maintained 7 days after admission. ConclusionHypolipidemia in SARS-CoV-2 infection may be secondary to an immune-inflammatory response, with complete recovery in survivors. Low LDL-c serum levels are independently associated with higher 30-day mortality in COVID-19 patients.
Aparisi ¨￠lvaro、Cus¨￠covich Iv¨￠n、Ladr¨?n Raquel、Carrasco-Moraleja Manuel、Rom¨￠n J. Alberto San、Uribarri Aitor、Andaluz-Ojeda David、Fuertes Ra¨2l、Garc¨aa-G¨?mez Mario、Nogales Leonor、Amat-Santos Ignacio J.、Candela Jordi、Due?as Carlos、Gonz¨￠lez Roberto、Hinojosa Williams、Iglesias-Echeverr¨aa Carolina、Calvo Dolores、Ybarra-Falc¨?n Cristina
Cardiology Department, Hospital Cl¨anico UniversitarioInternal Medicine Deparment, Hospital Cl¨anico Universitario de ValladolidCardiology Department, Hospital Cl¨anico UniversitarioCardiology Department, Hospital Cl¨anico UniversitarioCardiology Department, Hospital Cl¨anico Universitario||CIBERCV, Cardiology Department, Hospital Cl¨anico UniversitarioCardiology Department, Hospital Cl¨anico UniversitarioIntensive Care Unit Department, Hospital Cl¨anico Universitario de ValladolidMedicine School, University of ValladolidCardiology Department, Hospital Cl¨anico UniversitarioIntensive Care Unit Department, Hospital Cl¨anico Universitario de ValladolidCardiology Department, Hospital Cl¨anico Universitario||CIBERCV, Cardiology Department, Hospital Cl¨anico UniversitarioCardiology Department, Hospital Cl¨anico UniversitarioInternal Medicine Deparment, Hospital Cl¨anico Universitario de ValladolidInternal Medicine Deparment, Hospital Cl¨anico Universitario de ValladolidCardiology Department, Hospital Cl¨anico UniversitarioCardiology Department, Hospital Cl¨anico UniversitarioClinical analysis department, Hospital Cl¨anico Universitario de ValladolidCardiology Department, Hospital Cl¨anico Universitario
医药卫生理论医学研究方法临床医学
SARS-CoV-2COVID-19CoronavirusInflammationHigh-density lipoproteinLow-density lipoproteinTotal cholesterolTriglycerides
Aparisi ¨￠lvaro,Cus¨￠covich Iv¨￠n,Ladr¨?n Raquel,Carrasco-Moraleja Manuel,Rom¨￠n J. Alberto San,Uribarri Aitor,Andaluz-Ojeda David,Fuertes Ra¨2l,Garc¨aa-G¨?mez Mario,Nogales Leonor,Amat-Santos Ignacio J.,Candela Jordi,Due?as Carlos,Gonz¨￠lez Roberto,Hinojosa Williams,Iglesias-Echeverr¨aa Carolina,Calvo Dolores,Ybarra-Falc¨?n Cristina.Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2020.10.06.20207092.点此复制
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