Patterns of Autism Symptoms: Hidden Structure in the ADOS and ADI-R instruments
Patterns of Autism Symptoms: Hidden Structure in the ADOS and ADI-R instruments
ABSTRACT We simultaneously revisited the ADI-R and ADOS with a comprehensive data-analytics strategy. Here, the combination of pattern analysis algorithms and an extensive data resources (n=266 patients aged 7 to 49 years) allowed identifying coherent clinical constellations in and across ADI-R and ADOS assessments widespread in clinical practice. The collective results of the clustering and sparse regression approaches suggest that identifying autism subtypes and severity for a given individual may be most manifested in the social and communication domains of the ADI-R. Additionally, our quantitative investigation revealed that disease-specific patterns of ADI-R and ADOS scores can be uncovered when studying sex, age or level of FIQ in patients.
Lefort-Besnard J¨|r¨|my、Dumas Guillaume、Bzdok Danilo、Schilbach Leonhard、Vogeley Kai、Varoquaux Ga?l、Thirion Bertrand
Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University||J¨1lich Aachen Research Alliance (JARA) ?a Translational Brain MedicineHuman Genetics and Cognitive Functions University Paris Diderot, Sorbonne Paris Cit¨|||CNRS UMR3571 Genes, Synapses and Cognition, Institut Pasteur||Human Genetics and Cognitive Functions Unit, Institut PasteurDepartment of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University||J¨1lich Aachen Research Alliance (JARA) ?a Translational Brain Medicine||Parietal Team, INRIA, CEA, University Paris-SaclayMax-Planck Institute of PsychiatryDepartment of Psychiatry and Psychotherapy, University of CologneParietal Team, INRIA, CEA, University Paris-SaclayParietal Team, INRIA, CEA, University Paris-Saclay
神经病学、精神病学医学研究方法基础医学
Autism subtypessparse modelingmachine learningautism severity
Lefort-Besnard J¨|r¨|my,Dumas Guillaume,Bzdok Danilo,Schilbach Leonhard,Vogeley Kai,Varoquaux Ga?l,Thirion Bertrand.Patterns of Autism Symptoms: Hidden Structure in the ADOS and ADI-R instruments[EB/OL].(2025-03-28)[2025-05-02].https://www.medrxiv.org/content/10.1101/19007419.点此复制
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