Kidney injury molecule-1 is a potential receptor for SARS-CoV-2
Kidney injury molecule-1 is a potential receptor for SARS-CoV-2
Abstract COVID-19 patients present high incidence of kidney abnormalities, which are associated with poor prognosis and high mortality. Identification of SARS-CoV-2 in kidney of COVID-19 patients suggests renal tropism and direct infection. Presently, it is generally recognized that SARS-CoV-2 initiates invasion through binding of receptor-binding domain (RBD) of spike protein to host cell-membrane receptor ACE2, however, whether there is additional target of SARS-CoV-2 in kidney remains unclear. Kidney injury molecule-1 (KIM1) is a transmembrane protein that drastically up-regulated after renal injury. Here, binding between SARS-CoV2-RBD and the extracellular Ig V domain of KIM1 was identified by molecular simulations and co-immunoprecipitation, which was comparable in affinity to that of ACE2 to SARS-CoV-2. Moreover, KIM1 facilitated cell entry of SARS-CoV2-RBD, which was potently blockaded by a rationally designed KIM1-derived polypeptide. Together, the findings suggest KIM1 may mediate and exacerbate SARS-CoV-2 infection in a ‘vicious cycle’, and KIM1 could be further explored as a therapeutic target.
Chen Hong、Wang Xiaomu、Liu Xinran、Xiong Mingrui、Yang Chen、Chen Yuchen、Shen Ziwei、Yang Dong、Huang Kun、Zhang Yu
School of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology||Tongji-RongCheng Biomedical Center, Tongji Medical College, Huazhong University of Science & TechnologySchool of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology
基础医学分子生物学生理学
SARS-CoV-2COVID-19kidney diseaseskidney injury molecule-1coronavirus
Chen Hong,Wang Xiaomu,Liu Xinran,Xiong Mingrui,Yang Chen,Chen Yuchen,Shen Ziwei,Yang Dong,Huang Kun,Zhang Yu.Kidney injury molecule-1 is a potential receptor for SARS-CoV-2[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2020.10.09.334052.点此复制
评论