兔眼脉络膜上腔植入微电极阵列芯片的相关研究

ITo investigated the surgical procedure, complications, OCT appearance histological changes and the biocompatibllity of the of suprachoroidal Parylene-based multichannel electrode array in rabbit eyes. Methods A flat electrode array (parylene plate, platinum electrode) was developed and used for this study. After performing a scleral incision at 6mm from the limbus and placing an anchoring suture, the array was inserted into the suprachoroidal space in the posterior portion of the eye by direct observation under a microscope in 12 adult healthy chinchilla rabbit. The clinical examination including direct ophthalmoscope, and optical coherence tomography were performed in 3day, 14 day, and 1 month. The histological examinations were performed at 1month under light microscope. Results All the flat electrode arrays were successfully inserted into the Suprachoroidal space of rabbits. One eye injured the choroid and retina during the surgery and 5 with mild hemorrhage during the surgery. Optical coherence tomography demonstrated good position of the arrays and no significant retinal edema and retinal detachment were observed. Histological examination showed no significant inflammatory changes. Conclusions suprachoroidal multichannel electrode array insertion is a safe surgery, with little damage to the retina and choroid and without inflammatory change after surgery.