饲料中脱氧雪腐镰刀菌烯醇对昆明小鼠毒性的初步研究

Forty Kunming mice were divided into four groups, ten mice per group. Deoxynivalenol（DON）was added into the feed with the concenteation 0, 1, 3 and 5 mg/kg, respectively. After feeding 20 d, the growth performance and blood biochemical, haematological parameters，the weight of immune organ and histopathological change were monitored. At the high toxin levels (5mg/kg DON), the feed consumption, body weight gains, the weight of immune organ including thoracic gland and spleen), red blood cell count, mean corpuscular volume and blood platelets count were evidently lowered (p<0.05). The total protein, globulin, urea nitrigen，creatinine and triglyceride in serum were decreased significantly at high toxin levels (5mg/kg DON), however, the glutamate-pyruvate transaminase, glutamic oxalacetic transaminase, alkali phosphatase and albumin/globulion in the serum increased significantly(p<0.05). The histopathologic examination results showed that there were differecnt changes in organisms including liver,spleen, duodenum, stomach, kidney and thymus gland.