"特洛伊木马"型CMP-KDO合成酶抑制剂前药的设计与合成

MP-KDO synthase inhibitors are promising as novel antimicrobials against gram-negative bacteria, many of which are active molecules that cannot cross the membrane due to their high polarity.In order to solve this problem, this paper designed a prodrug iron carrier antimicrobial conjugate based on the design concept of iron carrier "Trojan horse" antimicrobial conjugate.The conjugate consists of three parts: iron carrier, linkage arm and active substance (KDO derivative).Using this strategy, a prodrug type iron carrier conjugate was successfully synthesized.