复方阿胶浆联合环磷酰胺对移植性小鼠lewis肺癌抑瘤率影响

Objective: To investigate the effects of compound e-Jiao slurry (CEJS) and Cyclophosphamide (CTX) on the inhibition of Lewis pulmonary carcinoma xenografts. Methods: Tumor xenografts models were prepared and randomly divided into six groups including the control group, CTX, CEJS with the dosages of high, middle and low. The volume and weight of tumor xenografts were measured in the experiment，the inhibition rate of tumor xenografts were calculated according to the data after the dissection. Results: The combination groups and CTX alone have an inhibition rate of 50% over, with CEJS group 25.88% . In every experimental group，the volume and weight all showed statistical significance compared with the control（p<0.05）.In the groups of different dosages of CEJS plus CTX, there is no statistical significance ,compared with the model control group（p>0.05）.Conclusion: CEJS can't obviously enhance the sensitivity of tumor xenografts to CTX, but at least has no impact on the inhibition effects of CTX.