Superior Colliculus-Projected GABAergic Retinal Ganglion Cells Mediate Looming-Evoked Flight Response
Superior Colliculus-Projected GABAergic Retinal Ganglion Cells Mediate Looming-Evoked Flight Response
Abstract The looming stimulus-evoked flight response is an experimental paradigm for studying innate defensive behaviors. However, how the visual looming stimulus is transmitted from the retina to the brain remains poorly understood. Here, we report that superior colliculus (SC)-projected GABAergic RGCs (spgRGCs) transmit the looming signal from the retina to the brain to mediate the looming-evoked flight behavior by releasing GABA. In the mouse retina, GABAergic RGCs are capable of projecting to many brain areas, including the SC. spgRGCs are mono-synaptically connected to the parvalbumin-positive SC neurons known to be required for the looming-evoked flight response. Optogenetic activation of spgRGCs triggers GABAergic responses in SC neurons. The ablation or silence of spgRGCs compromises looming-evoked flight response but not image-forming functions. Therefore, this study shows that spgRGCs control the looming-evoked flight response by regulating SC neurons via GABA, providing novel insight into the regulation of innate defensive behaviors.
Zeng Wen-Bo、Li Hua、Ren Chaoran、Xie Ting、Deng Qinqin、Lei Xinlan、Cai Danrui、Shen Yin、Huang Lu、Xu Fuqiang、Luo Min-Hua、Jin Sen、Luo Xue、Shen Kejiong
State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Wuhan Institute of Virology, Chinese Academy of SciencesStowers Institute for Medical ResearchGuangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University||Guangzhou Regenerative Medicine and Health Guangdong LaboratoryStowers Institute for Medical Research||Department of Anatomy and Cell Biology, University of Kansas School of MedicineEye center, Renmin Hospital of Wuhan UniversityEye center, Renmin Hospital of Wuhan UniversityEye center, Renmin Hospital of Wuhan UniversityEye center, Renmin Hospital of Wuhan University||Medical Research Institute, Wuhan UniversityDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University||Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan UniversityBrain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions||Centre for Brain Science, State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, CAS Centre for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Wuhan Institute of Virology, Chinese Academy of SciencesHUST-Suzhou Institute for Brainsmatics, JITRI Institute for BrainsmaticsEye center, Renmin Hospital of Wuhan UniversityEye center, Renmin Hospital of Wuhan University
生理学细胞生物学分子生物学
spgRGCsinnate defensive behaviorGABAloomingsuperior colliculusflight response
Zeng Wen-Bo,Li Hua,Ren Chaoran,Xie Ting,Deng Qinqin,Lei Xinlan,Cai Danrui,Shen Yin,Huang Lu,Xu Fuqiang,Luo Min-Hua,Jin Sen,Luo Xue,Shen Kejiong.Superior Colliculus-Projected GABAergic Retinal Ganglion Cells Mediate Looming-Evoked Flight Response[EB/OL].(2025-03-28)[2025-06-12].https://www.biorxiv.org/content/10.1101/2020.05.14.090167.点此复制
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