NK细胞在肿瘤免疫治疗中的研究进展

Natural killer (NK) cell is a special type of lymphocytes, which plays important role in the innate immune system and the adaptive immune system for directly identifing and killimg tumor cells without antigen sensitization. There are diverse mechanisms in NK cells-induced tumor cells suppression, including direct cytotoxic activity, antibody-dependent cell-mediated cytotoxicity (ADCC), secretion of multiple effector cytokines and so on. With the development of molecular biology of NK cells, NK cells have been used in clinical therapy. This review summarizes the mechanisms of NK cell activity and the treatment of tumor immunotherapy based on NK cells.