替米沙坦对动脉粥样硬化模型兔主动脉HGF、Met表达和巨噬细胞M1、M2亚型的影响

Objective To investigate the influence of telmisartan on blood lipids, the expressions of aortic hepatocyte growth Factor (HGF), mesenchymal-epithelial transition factor (Met), inducible nitric oxide synthase (iNOS) of M1 macrophage marker, arginase I (Arg I) of M2 macrophage maker and the development of atherosclerosis (AS). Methods Thirty New Zealand white rabbits were randomly assigned to control group，AS model group and telmisartan group respectively received a standard diet, high-cholesterol diet, and high-cholesterol diet plus 10 mg/kg/day telmisartan for twelve weeks. Serum blood lipids were detected on the twelfth week of experiment, the ratio of aortic intima-to-media thickness was detected by hematoxylin-eosin (HE) staining, HGF, Met, iNOS and Arg I expressions were detected by immunohistochemistry. Results Serum total cholesterol (Tch), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), triglyceride (TG), the ratio of aortic intima-to-media thickness, and aortic iNOS level of the AS model group were significantly higher than those of control group (P<0.05).Serum arterial HGF, Met and Arg I levels were significantly lower than those of control group (P<0.05). Serum TCh，LDL-C，the ratio of arterial intima-to-media thickness and aortic iNOS levels of the telmisartan group were significantly lower than those of AS model group (P<0.05), Serum HDL-c, aortic HGF, Met and Arg I levels of the telmisartan group were significantly higher than those of AS model group (P<0.05). Conclusion Telmisartan might suppress the development of experimental AS by improving blood lipid, increasing the expressions of aortic HGF，Met and M2 macrophage,while decreasing M1 macrophage.