自身免疫性疾病与1型糖尿病的治疗

utoimmune disease is a class of diseases endangering human health and one of them with organ specificity is type 1 diabetes(T1D). The T1D etiology is focusing on the combination functions of genetic and environmental factors and it was showed some self-reactive CD4 +and CD8+T cells were attacking the pancreatic β cells, resulting in the absolute lack of insulin. Identified self-antigens as insulin, glutamic acid decarboxylase (GAD65) triggered the reactions with the immune cells, cytokines, chemokines and inflammatory factors involved in the immune process. Nowadays, the T1D treatment already has some breakthroughs but oral tolerance curing autoimmune disease has attracted even more attentions .The study about the oral tolerance therapeutic mechanism will provide solid foundations for new clinical treatments of T1D.