三焦针法对阿尔兹海默症模型小鼠海马、皮质超微结构的影响
Effects of the acupuncture method of triple energizer on ultrastructure of the cortex and hippocampus CA1 region of 8-month-old swift aging mice (SAMP8).
老年性痴呆(Alzheimer's disease, AD)的特征之一是大脑线粒体功能障碍，其主要症状认知障碍反应在大脑的海马部和皮层部的CA1区。临床研究已证实三焦针法对阿尔兹海默症患者确有疗效。目的：研究三焦针法对痴呆小鼠皮质和海马CA1区超微结构的影响。方法：选取雄性SAMP8小鼠30只（随机分成三焦针刺组、非经穴针刺组、空白对照组）和10只SAMR1小鼠（正常对照组）。采用电子显微镜对小鼠大脑皮质和海马CA1区进行观察。结果：皮质和海马CA1区超微结构R1组正常，其余三组针刺组优于非穴组和对照组。结论：三焦针法对于改善阿尔兹海默症小鼠大脑超微结构确有疗效。
One of the characteristics of Alzheimer's disease is brain mitochondrial dysfunction.The cortex and hippocampus CA1 region pathologic changes lead to cognitive impairment which is the main symptom of AD.It has already been seen that the acupuncture method of triple energizer could improve the energy metabolism on patients with senile dementia．Objective：To investigate the influence of acupuncture method of triple energizer on ultrastructure of the cortex and hippocampus CA1 region of 8-month-old swift aging mice (SAMP8).Methods: The dementia mice were randomly divided into 3 groups: model group, acupuncture group and non-acupoint acupuncture group, and a normal group(SAMR1) group were set up. The mouse cerebral cortex and hippocampus CA1 region were observed by electron microscopy.Results: ultrastructure of the cortex and hippocampus CA1 region of the SAMR1 mice are almost normal. Acupuncture group had better expression on ultrastructure of the cortex and hippocampus CA1 region of SAMP8 mice than other two groups.Conclusion: the acupuncture method of triple energizer has markedly protective effects on ultrastructure of the cortex and hippocampus CA1 region of SAMP8 mice.
刘宇婧、郭睿婧、邢菁、付于、郝婷婷
中医学基础医学神经病学、精神病学
三焦针法透射电镜阿尔兹海默症
Sanjiao acupuncture methodElectron microscopylzheimer's disease
刘宇婧,郭睿婧,邢菁,付于,郝婷婷.三焦针法对阿尔兹海默症模型小鼠海马、皮质超微结构的影响[EB/OL].(2013-11-20)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201311-399.点此复制
评论