Effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infection among children and adolescents in Qatar
Effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infection among children and adolescents in Qatar
Abstract BackgroundThe BNT162b2 COVID-19 vaccine is authorized for children 5-11 years of age and adolescents 12-17 years of age, but in different dose sizes. We assessed BNT162b2 real-world effectiveness against SARS-CoV-2 infection among children and adolescents in Qatar. MethodsThree matched, retrospective, target-trial, cohort studies were conducted to compare incidence of SARS-CoV-2 infection in the national cohort of vaccinated individuals to incidence in the national cohort of unvaccinated individuals. Associations were estimated using Cox proportional-hazards regression models. ResultsEffectiveness of the 10 μg dose for children against Omicron infection was 25.7% (95% CI: 10.0-38.6%). It was highest at 49.6% (95% CI: 28.5-64.5%) right after the second dose, but waned rapidly thereafter and was negligible after 3 months. Effectiveness was 46.3% (95% CI: 21.5-63.3%) among those aged 5-7 years and 16.6% (?4.2-33.2%) among those aged 8-11 years. Effectiveness of the 30 μg dose for adolescents against Omicron infection was 30.6% (95% CI: 26.9-34.1%), but many adolescents were vaccinated months earlier. Effectiveness waned with time after the second dose. Effectiveness was 35.6% (95% CI: 31.2-39.6%) among those aged 12-14 years and 20.9% (13.8-27.4%) among those aged 15-17 years. Effectiveness of the 30 μg dose for adolescents against pre-Omicron infection was 87.6% (95% CI: 84.0-90.4%) and waned relatively slowly after the second dose. ConclusionsPediatric vaccination is associated with modest and rapidly waning protection against Omicron infection. Adolescent vaccination is associated with stronger and more durable protection, perhaps because of the larger dose size. Age at such young age appears to play a role in determining vaccine protection, with greater protection observed in younger than older children or adolescents.
AlMukdad Sawsan、Coyle Peter、Altarawneh Heba N.、Al-Khatib Hebah A.、Smatti Maria K.、Shaik Riyazuddin Mohammad、Abdul-Rahim Hanan F.、Al-Kuwari Mohamed Ghaith、Butt Adeel A.、Al-Khal Abdullatif、Al-Romaihi Hamad Eid、Latif Ali Nizar、Tang Patrick、Jeremijenko Andrew、Yassine Hadi M.、Al-Kanaani Zaina、Kaleeckal Anvar Hassan、Bertollini Roberto、Abu-Raddad Laith J.、Nasrallah Gheyath K.、Al-Thani Mohamed H.、Chemaitelly Hiam、Hasan Mohammad R.、Al-Kuwari Einas、Ayoub Houssein H.
Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University||World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine¨CQatar, Cornell UniversityHamad Medical Corporation||Biomedical Research Center, QU Health, Qatar University||Wellcome-Wolfson Institute for Experimental Medicine, Queens UniversityInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University||World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine¨CQatar, Cornell University||Department of Population Health Sciences, Weill Cornell Medicine, Cornell UniversityBiomedical Research Center, QU Health, Qatar University||Department of Biomedical Science, College of Health Sciences, QU Health, Qatar UniversityBiomedical Research Center, QU Health, Qatar University||Department of Biomedical Science, College of Health Sciences, QU Health, Qatar UniversityHamad Medical CorporationDepartment of Public Health, College of Health Sciences, QU Health, Qatar UniversityPrimary Health Care CorporationDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University||Hamad Medical Corporation||Department of Medicine, Weill Cornell Medicine, Cornell UniversityHamad Medical CorporationMinistry of Public HealthHamad Medical CorporationDepartment of Pathology, Sidra MedicineHamad Medical CorporationBiomedical Research Center, QU Health, Qatar University||Department of Biomedical Science, College of Health Sciences, QU Health, Qatar UniversityHamad Medical CorporationHamad Medical CorporationMinistry of Public HealthInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University||World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine¨CQatar, Cornell University||Department of Population Health Sciences, Weill Cornell Medicine, Cornell University||Department of Public Health, College of Health Sciences, QU Health, Qatar UniversityBiomedical Research Center, QU Health, Qatar University||Department of Biomedical Science, College of Health Sciences, QU Health, Qatar UniversityMinistry of Public HealthInfectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University||World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine¨CQatar, Cornell University||Department of Population Health Sciences, Weill Cornell Medicine, Cornell UniversityDepartment of Pathology, Sidra MedicineHamad Medical CorporationMathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences, Qatar University
预防医学医学研究方法医药卫生理论
COVID-19variantOmicronvaccinationcohort studyimmunityepidemiology
AlMukdad Sawsan,Coyle Peter,Altarawneh Heba N.,Al-Khatib Hebah A.,Smatti Maria K.,Shaik Riyazuddin Mohammad,Abdul-Rahim Hanan F.,Al-Kuwari Mohamed Ghaith,Butt Adeel A.,Al-Khal Abdullatif,Al-Romaihi Hamad Eid,Latif Ali Nizar,Tang Patrick,Jeremijenko Andrew,Yassine Hadi M.,Al-Kanaani Zaina,Kaleeckal Anvar Hassan,Bertollini Roberto,Abu-Raddad Laith J.,Nasrallah Gheyath K.,Al-Thani Mohamed H.,Chemaitelly Hiam,Hasan Mohammad R.,Al-Kuwari Einas,Ayoub Houssein H..Effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infection among children and adolescents in Qatar[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2022.07.26.22278045.点此复制
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