OA 基因在精神分裂症家系中的传递不平衡检验
Family-based Association Study of DAOA Gene and Schizophrenia
近年来的研究发现位于人类染色体13q22-q34区域的DAOA基因与精神分裂症高度关联。我们在126个中国汉族人三口之家中，对位于DAOA基因区域的三个单核苷酸多态性位点(SNPs:rs778294, rs778293和rs3918342)进行基因分型和统计分析。结果发现遗传标记rs778293和rs3918342与精神分裂症存在显著的传递不平衡。此外，我们构建单倍型进行分析发现，单倍型CAT在三口之家中表现出极其显著的传递不平衡。总之，我们的研究进一步支持了DAOA基因座位对精神分裂症的高度易感。
he DAOA gene has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 and rs3918342, and a highly significant under-transmission between haplotype CAT and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
刘海生、马雪红、闵自信、高成阁、宁启兰、吕社民、马捷、张蕊、亢万虎、孙健、赵文祥、张欢、王淑红
神经病学、精神病学遗传学基础医学
精神分裂症OA关联
SchizophreniaOAssociation
刘海生,马雪红,闵自信,高成阁,宁启兰,吕社民,马捷,张蕊,亢万虎,孙健,赵文祥,张欢,王淑红.OA 基因在精神分裂症家系中的传递不平衡检验[EB/OL].(2010-03-24)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201003-819.点此复制
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