苯并噻唑及其衍生物的合成研究进展

he synthetic methods of benzothiazole and its derivatives are reviewed systemically in this article. There are the most two important synthetic methods. The first one is based on the o-amino thiophenol, which is summarized from the four respects of reaction medium, reaction material, catalyst and reaction method. The second synthetic method is based on N-aryl thioamides which can be converted to benzothiazole by the method of sulfur negative ion's nucleophilic substitution, oxidative cyclization, benzyne intermediate and radical cyclization approach. There are some other synthetic methods for benzothiazole and its derivatives such as iodo-aniline, transformation of other heterocyclic, rearrangement reaction, benzoyl aniline or benzaldehyde aniline, catalytic oxidation and thermal decomposition of o-amino phenyl sulfide compounds that also have been introduced briefly in this paper.