Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model
Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model
Abstract Kleefstra syndrome in humans is characterized by general delay in development, intellectual disability and autistic features. The mouse model of this disease (Ehmt1+/-) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1+/- mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 minutes in a neutral, novel environment within a host-visitor setting. In 17 out of 74 trials there were defensive and offensive behaviors. Our key finding was that Ehmt1+/- mice displayed defensive postures, attacking and biting; in contrast, wild-type (WT) interacting with other WT did not enact such behaviors. Further, if there was a fight between an Ehmt1+/- and a WT mouse, it was always the Ehmt1+/- who initiated these behaviors.
Samanta Anumita、van den Brand Liz、Genzel Lisa、Negwer Moritz、Alonso Alejandra、Lobato Irene Navarro、van der Meij Jacqueline
Department of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDepartment of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDepartment of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDonders Institute for Brain, Cognition and Behaviour, RadboudUMCDepartment of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDepartment of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityDepartment of Neuroinformatics, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
KleefstraEHMT1Autism Spectrum Disordersocial behaviordefenseoffenseaggression
Samanta Anumita,van den Brand Liz,Genzel Lisa,Negwer Moritz,Alonso Alejandra,Lobato Irene Navarro,van der Meij Jacqueline.Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model[EB/OL].(2025-03-28)[2025-05-21].https://www.biorxiv.org/content/10.1101/2022.02.03.478985.点此复制
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