BSA共轭羟基磷灰石微米/纳米颗粒的可控合成

ontrollable synthesis of hydroxyapatite with different size and morphology has drawn more and more attention these days due to the Size/morphology-dependent cytotoxicity of hydroxyapatite in tumor treatments. In this study, a facile method was developed for the controllable synthesis of bovine serum albumin-conjugated micro- and nano- hydroxyapatite. Scanning electron microscope, Fourier transform infrared, energy dispersive system analysis and X-ray powder diffraction displayed that the pH value was the key factor affecting the morphology, size and crystal structure of products. The optimal pH value for the flocculatidn hydroxyapatite micro-crystals with size 1.82 ± 0.19 μm in the diameter and amorphous hydroxyapatite nanoparticles with size 167 ± 12 nm in the diameter was 7.97 and 6.5, respectively.