一锅法合成炔酯和炔腈
One-pot Synthesis of Propynoates and Propynenitriles
本文讲述的是一种高效转化合成酯或腈取代炔烃的方法。用一种实用的方法一锅法,在低温（-78或-60℃）和碱的作用下发生的反应而不是用任何过渡金属催化剂进行反应的。该方法在合成取代的乙炔上具有极大意义，碱的诱导效应表现出良好的官能团的适用性（高达28个例子）和高效率（高达92％的收率）,这也在克级规模反应上也能得到比较好的证明。
n efficient transformation towards ester or nitril substituted alkynes was herein described. The practical method-ology was conducted at low temperature (-78 or -60 ℃) in a one-pot manner with assistance of base rather than any transition metal catalysts. The base-induced protocol exhibits good functional groups tolerance (up to 28 examples) and high efficiency (up to 92% yields) towards substituted acetylenes of great synthetic significance, which was also well-demonstrated by the gram-scale reactions.
舒帆、董万荣、彭志鸿、安德烈
有机化学工业
有机化学炔酯炔腈一锅法
organic chemistry alkynoates propynenitriles one-pot
舒帆,董万荣,彭志鸿,安德烈.一锅法合成炔酯和炔腈[EB/OL].(2016-06-06)[2025-08-17].http://www.paper.edu.cn/releasepaper/content/201606-352.点此复制
评论