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Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

来源:medRxiv_logomedRxiv
英文摘要

Abstract AimPulse wave velocity independently predicts cardiovascular risk. Easy to use single cuff oscillometric methods are utilized in clinical practice to estimate pulse wave velocity. We applied the approach in master athletes to assess possible beneficial effects of lifelong exercise on vascular health. Furthermore, we compared single cuff measurements with a two-cuff method in another cohort. MethodsWe obtained single cuff upper arm oscillometric measurements thrice in 129 master athletes aged 35 to 86 years and estimated pulse wave velocity using the ArcSolver algorithm. We applied the same method in 24 healthy persons aged 24 to 55 years participating in a head down tilt bedrest study. In the latter group, we also obtained direct pulse wave velocity measurements using a thigh cuff. ResultsEstimated pulse velocity very highly correlated with age (R2= 0.90) in master athletes. Estimated pulse wave velocity values were located on the same regression line like values obtained in participants of the head down tilt bed rest study. The modest correlation between estimated and measured PWV (r2 0.40; p<0.05) was attenuated after adjusting for age; the mean difference between pulse wave velocity measurements was 1 m/s. ConclusionEstimated pulse wave velocity mainly reflects the entered age rather than true vascular properties and, therefore, failed detecting beneficial effects of life long exercise. FundingThe AGBRESA-Study was funded by the German Aerospace Center (DLR), the European Space Agency (ESA, contract number 4000113871/15/NL/PG) and the National Aeronautics and Space Administration (NASA, contract number 80JSC018P0078). FH received funding by the DLR and the German Federal Ministry of Economy and Technology, BMWi (50WB1816). SM, JT and JJ were supported by the Austrian Federal Ministry for Climate Action, Environment, Energy, Mobility, Innovation and Technology, BMK (SPACE4ALL Project, FFG No. 866761).

M?stl Stefan、Alvero-Cruz Jose Ramon、Rittweger J?rn、Tank Jens、Hoffmann Fabian、H?nemann Jan-Niklas、Jordan Jens

Department of Cardiovascular Aerospace Medicine, Institute of Aerospace Medicine, German Aerospace CenterDepartment of Human Physiology and Physical Sports Education, Faculty of Medicine, University of M¨¢lagaDepartment of Muscle and Bone Metabolism, Institute of Aerospace Medicine, German Aerospace CenterDepartment of Cardiovascular Aerospace Medicine, Institute of Aerospace Medicine, German Aerospace CenterDepartment of Cardiovascular Aerospace Medicine, Institute of Aerospace Medicine, German Aerospace Center||Department of Cardiology, University Hospital CologneDepartment of Cardiovascular Aerospace Medicine, Institute of Aerospace Medicine, German Aerospace Center||Department of Cardiology, University Hospital CologneInstitute of Aerospace Medicine, German Aerospace Center||Chair of Aerospace Medicine, University of Cologne

10.1101/2022.01.13.22268898

医学研究方法生理学航空航天技术

pulse wave velocityaginghypertension-mediated organ damagehemodynamicsprevention

M?stl Stefan,Alvero-Cruz Jose Ramon,Rittweger J?rn,Tank Jens,Hoffmann Fabian,H?nemann Jan-Niklas,Jordan Jens.Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods[EB/OL].(2025-03-28)[2025-05-07].https://www.medrxiv.org/content/10.1101/2022.01.13.22268898.点此复制

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