大鼠再生肝8种细胞的基因转录谱预示BE115434和X76129参与凝血反应
Gene transcript profiles of liver cells predicted that X76129 and BE115434 participate in blood coagulation in rat regenerating
为了解新基因BE115434和X76129与大鼠再生肝的凝血反应相关性，本文按张丽君[1]等方法分离大鼠再生肝8种细胞、检测它们的基因表达变化，分析新基因的序列同源性、共表达关系及参与的生理活动。结果表明，X76129与纤溶酶原激活酶基因Plaur同源和共表达，BE115434与纤维蛋白活化因子抑制蛋白serpind1同源和共表达。它们的表达变化预示X76129和BE115434参与大鼠再生肝的凝血反应。
o explore the correlation of new genes BE115434, X76129 and blood coagulation in rat liver regenerating, in this paper, isolation of rat 8 liver cell types, and detection of gene expression change were performed according to the method described by Zhang et al. And the genes sequence homology and co-expression relation, the possible physiological activities were analyzed. It was found that X76129 and Plaur which involved in profibrinolysin activating were homologous and co-expressed, and also was BE115434 and serpind1 which involved in inhibiting fibrin activation. Their expression change predicted X76129 and BE115434 participate in blood coagulation in rat regenerating.
高静、徐存拴、常翠芳
基础医学细胞生物学生理学
大鼠肝再生Rat Genome 230 2.0芯片基因表达谱分析凝血反应
liver regenerationRat Genome 230 2.0 arraygene transcription profilesblood coagulation
高静,徐存拴,常翠芳.大鼠再生肝8种细胞的基因转录谱预示BE115434和X76129参与凝血反应[EB/OL].(2010-01-14)[2025-06-14].http://www.paper.edu.cn/releasepaper/content/201001-622.点此复制
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