外周血中泡沫细胞的出现可能预示急性冠脉综合症的发生
Foam cells derived from mononuclear cells appearing in peripheral blood may predict the occurrence of acute coronary syndrome
目前,在临床实践中仍然没有一种简便的方法能够检测动脉粥样硬化斑块的破裂。单核细胞源性的泡沫细胞是在动脉斑块形成过程中出现的一种特征性的病理细胞。依照斑块形成和破裂的病理机制推断,一旦动脉斑块破裂单核细胞源性的泡沫细胞将会出现在循环外周血中。研究已经证实,斑块破裂后并非立即会导致动脉血管的堵塞或完全封闭,通常会有一定的时间间隔。期间如果能够检测到外周血中的泡沫细胞,将强烈提示循环中存在动脉斑块的破裂。
t present, there is not a conventional method which can detect atherosclerotic plaque rupture in clinical practice. Foam cells derived from Mononuclear cells are a kind of characteristic pathological cells in plaque formation. According to pathphysiologic mechanism of formation and rupture of intravascular plaque, we infer that foam cells which do not exist in peripheral blood originally will appear in peripheral blood after plaque rupture. And between plaque rupture and the occurrence of ACS, there is certain time interval. If foam cells detected in peripheral blood in the time interval, it will strongly indicate that intravascular plaque had broken.
徐多、崔翰斌
内科学基础医学临床医学
泡沫细胞外周血急性冠脉综合征
foam cellperipheral bloodacute coronary syndrome
徐多,崔翰斌.外周血中泡沫细胞的出现可能预示急性冠脉综合症的发生[EB/OL].(2013-04-28)[2025-08-21].http://www.paper.edu.cn/releasepaper/content/201304-609.点此复制
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