Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain
Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain
Abstract PurposeWe aimed to describe the demographics, cancer subtypes, comorbidities and outcomes of patients with a history of cancer with COVID-19 from March to June 2020. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza. MethodsWe conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, standardized to the Observational Medical Outcome Partnership common data model. Three cohorts of patients with a history of cancer were included: i) diagnosed with COVID-19, ii) hospitalized with COVID-19, and iii) hospitalized with influenza in 2017-2018. Patients were followed from index date to 30 days or death. We reported demographics, cancer subtypes, comorbidities, and 30-day outcomes. ResultsWe included 118,155 patients with a cancer history in the COVID-19 diagnosed and 41,939 in the COVID-19 hospitalized cohorts. The most frequent cancer subtypes were prostate and breast cancer (range: 5-19% and 1-14% in the diagnosed cohort, respectively). Hematological malignancies were also frequent, with non-Hodgkin’s lymphoma being among the 5 most common cancer subtypes in the diagnosed cohort. Overall, patients were more frequently aged above 65 years and had multiple comorbidities. Occurrence of death ranged from 8% to 14% and from 18% to 26% in the diagnosed and hospitalized COVID-19 cohorts, respectively. Patients hospitalized with influenza (n=242,960) had a similar distribution of cancer subtypes, sex, age and comorbidities but lower occurrence of adverse events. ConclusionPatients with a history of cancer and COVID-19 have advanced age, multiple comorbidities, and a high occurence of COVID-19-related events. Additionaly, hematological malignancies were frequent in these patients.This observational study provides epidemiologic characteristics that can inform clinical care and future etiological studies.
Tan Eng Hooi、Ostropolets Anna、Jonnagaddala Jitendra、Schilling Lisa M.、Nyberg Fredrik、Shah Nigam、Matheny Michael E.、Pistillo Andrea、Culhane Aedin C.、Falconer Thomas、Hester Laura、Hripcsak George、Jeon Hokyun、Morales Daniel R.、Prats-Uribe Albert、Soerjomataram Isabelle、Shah Karishma、Shen Yang、Spotniz Matthew、Subbian Vignesh、Trama Annalisa、Zhang Lin、Zhang Ying、Prieto-Alhambra Daniel、Recalde Martina、Alser Osaid、DeFalco Frank、Areia Carlos、Casajust Paula、Puente Diana、Alshammari Thamir M.、Roel Elena、Dawoud Dalia、Reich Christian G.、Posada Jos¨| D.、Sena Anthony G.、Suchard Marc A.、Rivera Donna、Lai Lana Y.H.、Fern¨￠ndez-Bertol¨an Sergio、Kostka Kristin、Blacketer Clair、Gong Mengchun、Alghoul Heba、Ryan Patrick、Duvall Scott L.、Golozar Asieh、Carter William、Duarte-Salles Talita、Ahmed Waheed-Ul-Rahman、Natarajan Karthik、Arag¨?n Mar¨aa、Lynch Kristine E.
Centre for Statistics in Medicine, NDORMS, University of OxfordDepartment of Biomedical Informatics, Columbia UniversitySchool of Public Health and Community MedicineData Science to Patient Value Program, Department of Medicine, University of Colorado Anschutz Medical CampusSchool of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgDepartment of Medicine, School of Medicine, Stanford UniversityTennessee Valley Healthcare System, Veterans Affairs Medical Center||Department of Biomedical Informatics, Vanderbilt University Medical CenterFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)Department of Data Science, Dana-Farber Cancer Institute||Department of Biostatistics, Harvard TH Chan School of Public HealthDepartment of Biomedical Informatics, Columbia University||New York-Presbyterian HospitalAssociate Director, Epidemiology, Janssen Research and DevelopmentDepartment of Biomedical Informatics, Columbia University||New York-Presbyterian HospitalDepartment of Biomedical Sciences, Ajou University Graduate School of MedicineDivision of Population Health and Genomics, University of Dundee||University of Southern DenmarkCentre for Statistics in Medicine, NDORMS, University of OxfordSection of Cancer Surveillance, International Agency for Research on CancerNDORMS, University of Oxford, Botnar Research CentreDigital Health China Technologies Co., LTD, BeijingDepartment of Biomedical Informatics, Columbia UniversityCollege of Engineering, The University of Arizona, TucsonFondazione IRCSS Istituto Nazionale dei TumoriSchool of Population Medicine and Public Health, Peking Union Medical College||School of Population Health and Global Health, The University of MelbourneDigital Health China Technologies Co., LTD, BeijingCentre for Statistics in Medicine, NDORMS, University of OxfordFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)||Universitat Aut¨°noma de BarcelonaMassachusetts General Hospital, Harvard Medical SchoolJanssen Research and DevelopmentNuffield Department of Clinical Neurosciences, University of OxfordReal-World Evidence, Trial Form SupportFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)||Universitat Aut¨°noma de BarcelonaMedication Safety Research Chair, King Saud UniversityFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)||Universitat Aut¨°noma de BarcelonaFaculty of Pharmacy, Cairo UniversityReal World SolutionsDepartment of Medicine, School of Medicine, Stanford UniversityJanssen Research and Development||Department of Medical Informatics, Erasmus University Medical CenterFielding School of Public Health, University of CaliforniaDivision of Cancer Control and Population Sciences, National Cancer InstituteSchool of Medical Sciences, University of ManchesterFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)Real World SolutionsJanssen Research and DevelopmentDigital Health China Technologies Co., LTD, BeijingFaculty of Medicine, Islamic University of GazaJanssen Research and Development||Department of Biomedical Informatics, Columbia UniversityVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System||Department of Internal Medicine, University of Utah School of MedicineDepartment of Epidemiology, Johns Hopkins School of Public||Pharmacoepidemiology, Regeneron PharmaceuticalsData Science to Patient Value Program, Department of Medicine, University of Colorado Anschutz Medical CampusFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)NDORMS, University of Oxford, Botnar Research Centre||College of Medicine and Health, University of Exeter, St Luke?ˉs Campus, Heavitree RoadDepartment of Biomedical Informatics, Columbia University||New York-Presbyterian HospitalFundaci¨? Institut Universitari per a la recerca a l?ˉAtenci¨? Prim¨¤ria de Salut Jordi Gol i Gurina (IDIAPJGol)VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System||Department of Internal Medicine, University of Utah School of Medicine
肿瘤学医学研究方法医药卫生理论
COVID-19SARS-CoV-2cancercharacterizationhospital admissionmortality
Tan Eng Hooi,Ostropolets Anna,Jonnagaddala Jitendra,Schilling Lisa M.,Nyberg Fredrik,Shah Nigam,Matheny Michael E.,Pistillo Andrea,Culhane Aedin C.,Falconer Thomas,Hester Laura,Hripcsak George,Jeon Hokyun,Morales Daniel R.,Prats-Uribe Albert,Soerjomataram Isabelle,Shah Karishma,Shen Yang,Spotniz Matthew,Subbian Vignesh,Trama Annalisa,Zhang Lin,Zhang Ying,Prieto-Alhambra Daniel,Recalde Martina,Alser Osaid,DeFalco Frank,Areia Carlos,Casajust Paula,Puente Diana,Alshammari Thamir M.,Roel Elena,Dawoud Dalia,Reich Christian G.,Posada Jos¨| D.,Sena Anthony G.,Suchard Marc A.,Rivera Donna,Lai Lana Y.H.,Fern¨￠ndez-Bertol¨an Sergio,Kostka Kristin,Blacketer Clair,Gong Mengchun,Alghoul Heba,Ryan Patrick,Duvall Scott L.,Golozar Asieh,Carter William,Duarte-Salles Talita,Ahmed Waheed-Ul-Rahman,Natarajan Karthik,Arag¨?n Mar¨aa,Lynch Kristine E..Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain[EB/OL].(2025-03-28)[2025-06-10].https://www.medrxiv.org/content/10.1101/2021.01.12.21249672.点此复制
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