微小病变伴IgA沉积患者的临床病理分析

【Background】Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis with various histological and clinical phenotypes. Nephrotic syndrome (NS) is an unusual manifestation of IgAN. Patients with IgAN demonstrating as NS with mild microhematuria or without hematuria called minimal change disease (MCD) with mesangial IgA deposition (MCD-IgA). The relationship between the patients with IgAN and MCD-IgA remains controversial, there is few studies of its pathogenesis. 【Objectives】To investigate the clinical and the pathogenic differences between MCD-IgA and IgAN.【Methods】Thirty-three MCD-IgA patients were enrolled, and the clinical and pathological conditions were anlysised.【Results】Among 33 MCD-IgA patients, approximately 57.57% of patients had no hematuria. According to the hematuria condition, the pations divided into two groups, between the two groups pathological changes were significant different. In the cell counting, compared with H-IgAN, the mesangial cells in glomerular of MCD-IgA were reduced significantly, and the podocytes were increased. Compared with MCD, the number of three types of cells in MCD-IgA patients had no significant differences.