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基于生物信息学探讨杜仲叶治疗癫痫的作用机制和物质基础

o Explore the Mechanism and Material Basis of Eucommiae Folium in the Treatment of Epilepsy Based on Bioinformatics Analysis

中文摘要英文摘要

目的 基于生物信息学技术研究杜仲叶治疗癫痫的作用机制和物质基础。 方法 运用LC-MS技术获得杜仲叶成分,并通过SuperPred数据库和GeneCards等数据库获得成分和疾病靶点, 运用Cytoscape软件建立网络图;使用Metascape数据库进行富集分析;使用CB-dock软件进行分子对接。 结果 共筛选出杜仲叶113个活性成分及531个靶点,29880个癫痫疾病靶点,57个交集靶点,9个核心靶点;主要涉及的信号通路包括癌症通路、5-羟色胺突触等通路有关。 结论 杜仲叶治疗癫痫的作用机制可能与炎症反应相关,为进一步药理学实验提供了科学的理论依据。

Objective Research on the mechanism and substance basis of Eucommia Folium treating epilepsy based on bioinformatics technology. Methods Using LC-MS technology to obtain the components of Eucommiae Folium, and obtaining the components and disease targets through the SuperPred database and GeneCards database. Using Cytoscape software to establish network maps; Perform enrichment analysis using Metascape database; Use CB-dock software for molecular docking. Results A total of 113 active ingredients and 531 target points were screened from the Eucommiae Folium, with 29880 epilepsy disease target points, 57 intersection target points and nine core target points. The main related signaling pathways include cancer pathways, serotonin synapse, etc. Conclusions The mechanism of Eucommiae Folium in treating epilepsy may be related to inflammation response, providing a scientific theoretical basis for further pharmacological experiments.

李煦照、张帅男、唐文雅、魏明星

10.12074/202308.00756V1

医药卫生理论神经病学、精神病学生物科学研究方法、生物科学研究技术

杜仲叶癫痫生物信息学分子对接作用机制物质基础

Eucommiae FoliumEpilepsyBioinformaticsMolecular dockingMechanism of actionMaterial basis

李煦照,张帅男,唐文雅,魏明星.基于生物信息学探讨杜仲叶治疗癫痫的作用机制和物质基础[EB/OL].(2023-08-28)[2025-08-18].https://chinaxiv.org/abs/202308.00756.点此复制

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