Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition
Abstract Improving deteriorated sensorimotor functions in older individuals is a social necessity in a super-aging society. Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. Here, we examined whether bimanual digit exercises, which can train the interhemispheric inhibitory system, improve deteriorated hand/finger dexterity in older adults. Forty-eight healthy, right-handed, older adults (65-78 years old) were divided into two groups, i.e., the bimanual (BM) digit training and right-hand (RH) training groups, and intensive daily training was performed for 2 months. Before and after the training, we evaluated individual right hand/finger dexterity using a peg task, and the individual state of interhemispheric sensorimotor inhibition by analyzing ipsilateral sensorimotor deactivation via functional magnetic resonance imaging when participants experienced a kinesthetic illusory movement of the right-hand without performing any motor tasks. Before training, the degree of reduction/loss of ipsilateral motor-cortical deactivation was associated with dexterity deterioration. After training, the dexterity improved only in the BM group, and the dexterity improvement was correlated with reduction in ipsilateral motor-cortical activity. The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults.
Naito Eiichi、Okamoto Hideya、Kamimukai Chikako、Hirose Satoshi、Asada Minoru、Morita Tomoyo、Kimura Nodoka
Center for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology (NICT)||Graduate School of Frontier Biosciences, Osaka UniversityGlobal Research & Development Department, Element Technology Research & Development Section, Mizuno CorporationGlobal Research & Development Department, Element Technology Research & Development Section, Mizuno CorporationCenter for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology (NICT)||Graduate School of Frontier Biosciences, Osaka UniversityCenter for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology (NICT)||Institute for Open and Transdisciplinary Research Initiatives, Osaka UniversityCenter for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology (NICT)||Institute for Open and Transdisciplinary Research Initiatives, Osaka UniversityCenter for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology (NICT)
神经病学、精神病学基础医学医学研究方法
bimanual trainingfunctional magnetic resonance imaginghand dexteritynormal agingtranscallosal inhibition
Naito Eiichi,Okamoto Hideya,Kamimukai Chikako,Hirose Satoshi,Asada Minoru,Morita Tomoyo,Kimura Nodoka.Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition[EB/OL].(2025-03-28)[2025-05-03].https://www.biorxiv.org/content/10.1101/2021.05.21.445083.点此复制
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