Social problems and brain structure development following childhood mild traumatic brain injury
Social problems and brain structure development following childhood mild traumatic brain injury
Abstract Childhood mild traumatic brain injury (mTBI) is associated with elevated risk of developing social problems, which may be underpinned by changes in the structural developmental trajectory of the social brain, a network of cortical regions supporting social cognition and behavior. However, limited sample sizes and cross-sectional designs generally used in neuroimaging studies of pediatric TBI have prevented explorations of this hypothesis. This longitudinal retrospective study examined the development of parent-reported social problems and cortical thickness in social brain regions following childhood mTBI using data from the large population-based Adolescent Brain Cognitive Development (ABCD) Study. Two-group latent change score models revealed different developmental trajectories from ages 10 to 12 years in social problems between children with (n=345) and without (n=7,089) mTBI. Children with mTBI showed higher levels of social problems than controls at age 10. Then, social problems decreased over 2 years, but still remained higher than in controls in which they stayed stable. Both groups showed similar decreases in social brain cortical thickness between ages 10 and 12 years. Further studies providing detailed information on the injury mechanism and acute symptoms are needed to better understand individual differences in social impairment and brain development in pediatric TBI.
D¨|geilh Fanny、Soest Tilmann von、Koerte Inga K.、Ferschmann Lia、Beer Joanne C.、Tamnes Christian K.、Gaubert Malo
University of Rennes 1, CNRS, Inria, Inserm, IRISA UMR 6074, EMPENN ¨C ERL U 1228||Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig-Maximilians-Universit?tPROMENTA Research Center, Department of Psychology, University of OsloDepartment of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig-Maximilians-Universit?t||Psychiatric Neuroimaging Laboratory, Brigham and Women?ˉs Hospital, Harvard Medical School||Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universit?t||Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolPROMENTA Research Center, Department of Psychology, University of OsloDepartment of Biostatistics, Epidemiology and Informatics, University of PennsylvaniaPROMENTA Research Center, Department of Psychology, University of Oslo||NORMENT, Institute of Clinical Medicine, University of Oslo||Department of Psychiatric Research, Diakonhjemmet HospitalUniversity of Rennes 1, CNRS, Inria, Inserm, IRISA UMR 6074, EMPENN ¨C ERL U 1228||Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig-Maximilians-Universit?t
神经病学、精神病学医学研究方法基础医学
Traumatic brain injuryConcussionBrain developmentSocial problemsCortical thickness
D¨|geilh Fanny,Soest Tilmann von,Koerte Inga K.,Ferschmann Lia,Beer Joanne C.,Tamnes Christian K.,Gaubert Malo.Social problems and brain structure development following childhood mild traumatic brain injury[EB/OL].(2025-03-28)[2025-04-27].https://www.medrxiv.org/content/10.1101/2022.09.20.22280146.点此复制
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