β-arrestins在中枢神经系统疾病中的研究进展

β-arrestins is a type of adaptor protein, which mediated the endocytosis of surface receptors or non-receptor proteins. β-arrestins, which negatively regulating G protein signal, are now well proven to be a multifunctional adaptor protein to desensitize activated G protein-coupled receptors (GPCRs). It can selectively stabilize only a subset of receptor conformations and thus preferentially activating certain signaling mechanisms, participating in a broad range of human physical and disease processes. Here, we provide an overview of the receptor endocytosis by β-arrestins and the study of β-arrestins in central nervous system diseases.