The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals
ABSTRACT ObjectivesA decrease in blood cell counts, especially lymphocytes and eosinophils, has been described in patients with severe SARS-CoV-2 (COVID-19), but there is no knowledge of the potential role of their recovery in these patients’ prognosis. This article aims to analyse the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. DesignThis work is a multicentre, retrospective, cohort study of 9,644 hospitalised patients with confirmed COVID-19 from the Spanish Society of Internal Medicine’s SEMI-COVID-19 Registry. SettingThis study examined patients hospitalised in 147 hospitals throughout Spain. ParticipantsThis work analysed 9,644 patients (57.12% male) out of a cohort of 12,826 patients ≥18 years of age hospitalised with COVID-19 in Spain included in the SEMI-COVID-19 Registry as of 29 May 2020. Main outcome measuresThe main outcome measure of this work is the effect of blood cell depletion and blood cell recovery on mortality due to COVID-19. Univariate analysis was performed to determine possible predictors of death and then multivariate analysis was carried out to control for potential confounders. ResultsAn increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs 22.6% in non-recoverers, OR 0.234 [95% CI, 0.154 to 0.354]) and lower complication rates, especially regarding to development of acute respiratory distress syndrome (8% vs 20.1%, p=0.000) and ICU admission (5.4% vs 10.8%, p=0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor. ConclusionEosinophil recovery in patients with COVID-19 is a reliable marker of a good prognosis that is independent of prior treatment. This finding could be used to guide discharge decisions.
P¨|rez Jos¨| Luis Beato、Lopez Irene Casado、Bermejo Carlos Lumbreras、Castro Santiago Jes¨2s Freire、Bailon Manuel Mendez、Gamboa Jeffrey Oskar Magallanes、Garc¨aa Andr¨|s Gonz¨￠lez、Aizpuru Eva Mar¨aa Fonseca、Fenoll Rosa Garc¨aa、Fern¨￠ndez Carmen Su¨￠rez、Vieitez Anxela Crestelo、Arostegui Asier Aranguren、N¨2?ez Juan Antonio Vargas、Monge Daniel Monge、Erdozain Ainara Coduras、Madrazo Manuel、Epelde Francisco、Fern¨￠ndez Francisco Arnalich、Gonz¨￠lez Mar¨aa Mateos、Amigo Jose Loureiro、Fontan Paula Maria Pesqueira、Gonzalo Elena Sierra、Fraile Isabel Perales、Santos Juan Miguel Ant¨?n、for the SEMI-COVID-19 Network、Cilleros Carmen Martinez
Internal Medicine Department, Albacete University Hospital ComplexInternal Medicine Department, Infanta Cristina University HospitalInternal Medicine Department, 12 de Octubre University HospitalInternal Medicine Department, A Coru?a University HospitalInternal Medicine Department, Clinico San Carlos HospitalInternal Medicine Department, Nuestra Se?ora del Prado Hospital, Talavera de la Reina (Toledo)Internal Medicine Department, Ram¨?n y Cajal University HospitalInternal Medicine Department, Cabue?es HospitalInternal Medicine Department, Miguel Servet HospitalInternal Medicine Department, La Princesa University HospitalInternal Medicine Department, Royo Villanova HospitalInternal Medicine Department, Urduliz Alfredo Espinosa HospitalInternal Medicine Department, Puerta de Hierro University HospitalInternal Medicine Department, Segovia Hospital ComplexInternal Medicine Department, Santa Marina HospitalInternal Medicine Department, Dr. Peset University HospitalInternal Medicine Department, Parc Tauli HospitalInternal Medicine Department, La Paz University HospitalInternal Medicine Department, Infanta Cristina University HospitalInternal Medicine Department, Mois¨¨s Broggi Hospital, Sant Joan Desp¨a (Barcelona)Internal Medicine Department, Santiago Clinical Hospital, Santiago de Compostela (A Coru?a)Pathology Department, Infanta Cristina University HospitalInternal Medicine Department, Infanta Sof¨aa Hospital, San Sebasti¨￠n de los Reyes (Madrid)Internal Medicine Department, Infanta Cristina University HospitalInternal Medicine Department, HLA Moncloa Hospital
医药卫生理论医学研究方法内科学
2019-nCoVSARS-CoV-2coronavirusCOVID-19eosinophilprognosis
P¨|rez Jos¨| Luis Beato,Lopez Irene Casado,Bermejo Carlos Lumbreras,Castro Santiago Jes¨2s Freire,Bailon Manuel Mendez,Gamboa Jeffrey Oskar Magallanes,Garc¨aa Andr¨|s Gonz¨￠lez,Aizpuru Eva Mar¨aa Fonseca,Fenoll Rosa Garc¨aa,Fern¨￠ndez Carmen Su¨￠rez,Vieitez Anxela Crestelo,Arostegui Asier Aranguren,N¨2?ez Juan Antonio Vargas,Monge Daniel Monge,Erdozain Ainara Coduras,Madrazo Manuel,Epelde Francisco,Fern¨￠ndez Francisco Arnalich,Gonz¨￠lez Mar¨aa Mateos,Amigo Jose Loureiro,Fontan Paula Maria Pesqueira,Gonzalo Elena Sierra,Fraile Isabel Perales,Santos Juan Miguel Ant¨?n,for the SEMI-COVID-19 Network,Cilleros Carmen Martinez.The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2020.08.18.20172874.点此复制
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